GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs9858542 | 1 | rs1131095 | chr3:49714225 | AMT | chr3:49454212-49460012:- | 0.11 | 3.67 | 0.000256 | Crohn's disease;Ulcerative colitis |
| BRCA | cis | rs111803315 | 1 | rs113112586 | chr14:59969142 | C14orf149 | chr14:59939406-59951126:- | -0.24 | -3.49 | 0.000507 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs113112586 | chr14:59969142 | JKAMP | chr14:59951161-59972080:+ | 0.33 | 5.73 | 1.28E-8 | Schizophrenia |
| BRCA | cis | rs892864 | 1 | rs113143821 | chr5:127893353 | FBN2 | chr5:127593602-127873916:- | 0.28 | 5.2 | 2.33E-7 | Multiple system atrophy |
| BRCA | cis | rs6951245 | 1 | rs113146460 | chr7:1105164 | ZFAND2A | chr7:1192544-1199855:- | -0.31 | -6.05 | 2.01E-9 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BRCA | cis | rs1853207 | 1 | rs113244272 | chr10:96400221 | C10orf129 | chr10:96953957-96988685:+ | 0.34 | 5.4 | 8.04E-8 | Blood metabolite levels |
| BRCA | cis | rs1853207 | 1 | rs113251361 | chr10:96626220 | C10orf129 | chr10:96953957-96988685:+ | 0.37 | 5.96 | 3.52E-9 | Blood metabolite levels |
| BRCA | cis | rs755109 | 1 | rs113315674 | chr9:100720053 | C9orf156 | chr9:100666772-100684852:- | -0.16 | -4.44 | 9.82E-6 | Quantitative traits |
| BRCA | cis | rs2953174 | 1 | rs1133353 | chr2:241522267 | CAPN10 | chr2:241526145-241557122:+ | 0.11 | 3.77 | 0.000174 | Bipolar disorder |
| BRCA | cis | rs111803315 | 1 | rs113337957 | chr14:59967329 | C14orf149 | chr14:59939406-59951126:- | -0.24 | -3.49 | 0.000507 | Schizophrenia |
| BRCA | cis | rs111803315 | 1 | rs113337957 | chr14:59967329 | JKAMP | chr14:59951161-59972080:+ | 0.33 | 5.73 | 1.28E-8 | Schizophrenia |
| BRCA | cis | rs4787484 | 1 | rs11344 | chr16:29910518 | ALDOA | chr16:30064472-30081734:+ | 0.11 | 3.8 | 0.000152 | Response to taxane treatment (placlitaxel) |
| BRCA | cis | rs4787484 | 1 | rs11344 | chr16:29910518 | LOC440356 | chr16:29875004-29879374:+ | -0.23 | -6.4 | 2.34E-10 | Response to taxane treatment (placlitaxel) |
| BRCA | cis | rs4787484 | 1 | rs11344 | chr16:29910518 | TBX6 | chr16:30097117-30103208:- | 0.15 | 4.41 | 1.13E-5 | Response to taxane treatment (placlitaxel) |
| BRCA | cis | rs12468226 | 1 | rs113491584 | chr2:203196447 | NOP58 | chr2:203130515-203168382:+ | 0.15 | 3.47 | 0.000543 | Urate levels |